Protein profiling and network enrichment analysis in individuals before and after the onset of rheumatoid arthritis.

ABSTRACT:

Background

Antibodies and upregulated cytokines and chemokines predate the onset of rheumatoid arthritis (RA) symptoms. We aimed to identify the pathways related to the early processes leading to RA development, as well as potential novel biomarkers, using multiple protein analyses.

Methods

A case-control study was conducted within the Biobank of northern Sweden. The plasma samples from 118 pre-symptomatic individuals (207 samples; median predating time 4.1 years), 79 early RA patients, and 74 matched controls were analyzed. The levels of 122 unique proteins with an acknowledged relationship to autoimmunity were analyzed using 153 antibodies and a bead-based multiplex system (FlexMap3D; Luminex Corp.). The data were analyzed using multifactorial linear regression model, rand

SUBMITTER: Brink M 

PROVIDER: S-EPMC6915963 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature