Role of Nrf2 in inflammatory response in lung of mice exposed to zinc oxide nanoparticles.

ABSTRACT:

Background

Zinc oxide nanoparticles (ZnO-NPs) are widely used in many industrial sectors and previous studies have reported that exposure of the lungs to ZnO-NPs induces both acute and/or chronic pulmonary inflammation, but the exact mechanism underlying such response remains elusive. This study investigated the role of nuclear factor-erythroid 2-related factor (Nrf2) in pulmonary inflammation induced by exposure to ZnO-NPs using Nrf2 null (Nrf2^-/-) mice.

Methods

Twenty-four male Nrf2^-/- mice and thirty male wild type C57BL/6 J mice were divided into three groups of eight and ten each respectively, and exposed once to ZnO-NPs at 0, 10, 30 μg/mouse by pharyngeal aspiration. At 14 days after the exposure to ZnO-NPs, bronchoalveolar lavage fluid (BALF) and

SUBMITTER: Sehsah R 

PROVIDER: S-EPMC6915997 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature