Myocardial characterization in pre-dialysis chronic kidney disease: a study of prevalence, patterns and outcomes.

ABSTRACT:

Background

Late gadolinium enhancement (LGE) using cardiac magnetic resonance (CMR) characterizes myocardial disease and predicts an adverse cardiovascular (CV) prognosis. Myocardial abnormalities, are present in early chronic kidney disease (CKD). To date there are no data defining prevalence, pattern and clinical implications of LGE-CMR in CKD.

Methods

Patients with pre-dialysis CKD (stage 2-5) attending specialist renal clinics at University Hospital Birmingham (UK) who underwent gadolinium enhanced CMR (1.5 T) between 2005 and 2017 were included. The patterns and presence (LGEpos) / absence (LGEneg) of LGE were assessed by two blinded observers. Association between LGE and CV outcomes were assessed.

Results

In total, 159 patients received gadolinium (male 61%, mea

SUBMITTER: Price AM 

PROVIDER: S-EPMC6916031 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature