Oral health and plaque microbial profile in juvenile idiopathic arthritis.

ABSTRACT:

Background

The oral microbiota has been implicated in the pathogenesis of rheumatoid arthritis through activation of mucosal immunity. This study tested for associations between oral health, microbial communities and juvenile idiopathic arthritis (JIA).

Methods

A cross-sectional exploratory study of subjects aged 10-18 years with oligoarticular, extended oligoarticular and polyarticular JIA was conducted. Control groups included pediatric dental clinic patients and healthy volunteers. The primary aim was to test for an association between dental health indices and JIA; the secondary aim was to characterize the microbial profile of supragingival plaque using 16S rRNA gene sequencing.

Results

The study included 85 patients with JIA, 62 dental patients and 11 healthy chi

SUBMITTER: Grevich S 

PROVIDER: S-EPMC6916162 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature