Impaired neural habituation to neutral faces in families genetically enriched for social anxiety disorder.

ABSTRACT:

Background

Social anxiety disorder (SAD) is an incapacitating disorder running in families. Previous work associated social fearfulness with a failure to habituate, but the habituation response to neutral faces has, as of yet, not been investigated in patients with SAD and their family members concurrently. Here, we examined whether impaired habituation to neutral faces is a putative neurobiological endophenotype of SAD by using data from the multiplex and multigenerational Leiden Family Lab study on SAD.

Methods

Participants (n = 110; age, 9.2 - 61.5 years) performed a habituation paradigm involving neutral faces, as these are strong social stimuli with an ambiguous meaning. We used functional magnetic resonance imaging data to investigate whether brain activation related t

SUBMITTER: Bas-Hoogendam JM 

PROVIDER: S-EPMC6916167 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature