Statins for primary prevention of cardiovascular disease and the risk of acute kidney injury.

ABSTRACT:

Purpose

To investigate the risk of acute kidney injury (AKI) in subjects initiating statin therapy for primary prevention of cardiovascular disease (CVD).

Methods

A nationwide cohort study using French hospital discharge and claims databases was performed, studying subjects from the general population aged 40 to 75 years in 2009, with no history of CVD and no lipid-lowering drugs during the preceding 3-year period, followed for up to 7 years. Exposure to statins (type, dose, and time since first use) and to other drugs for CVD risk was assessed. The primary outcome was hospital admission for AKI.

Results

The cohort included 8 236 279 subjects, 818 432 of whom initiated a statin for primary prevention. During 598 487 785 person-months exposed to statins, 700 events wer

SUBMITTER: Coste J 

PROVIDER: S-EPMC6916201 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature