Maternal environmental risk factors and the development of internalizing and externalizing problems in childhood: The complex role of genetic factors.

ABSTRACT: The development of problem behavior in children is associated with exposure to environmental factors, including the maternal environment. Both are influenced by genetic factors, which may also be correlated, that is, environmental risk and problem behavior in children might be influenced by partly the same genetic factors. In addition, environmental and genetic factors could interact with each other increasing the risk of problem behavior in children. To date, limited research investigated these mechanisms in a genome-wide approach. Therefore, the goal of this study was to investigate the association between genetic risk for psychiatric and related traits, as indicated by polygenetic risk scores (PRSs), exposure to previously identified maternal risk factors, and problem behavior in a samp

SUBMITTER: Ensink JBM 

PROVIDER: S-EPMC6916208 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature