Inferring Pareto-optimal reconciliations across multiple event costs under the duplication-loss-coalescence model.

ABSTRACT:

Background

Reconciliation methods are widely used to explain incongruence between a gene tree and species tree. However, the common approach of inferring maximum parsimony reconciliations (MPRs) relies on user-defined costs for each type of event, which can be difficult to estimate. Prior work has explored the relationship between event costs and maximum parsimony reconciliations in the duplication-loss and duplication-transfer-loss models, but no studies have addressed this relationship in the more complicated duplication-loss-coalescence model.

Results

We provide a fixed-parameter tractable algorithm for computing Pareto-optimal reconciliations and recording all events that arise in those reconciliations, along with their frequencies. We apply this method to a case study o

SUBMITTER: Mawhorter R 

PROVIDER: S-EPMC6916210 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature