FcγRIIIa receptor polymorphism influences NK cell mediated ADCC activity against HIV.

ABSTRACT:

Background

HIV-specific Antibody Dependent Cell Cytotoxicity (ADCC) has shown to be important in HIV control and resistance. The ADCC is mediated primarily by natural killer cell activated through the binding of FcγRIIIa receptor to the Fc portion of antibody bound to the antigen expressed on the infected cells. However, no data is available on the influence of the polymorphism in FcγRIIIa receptor on HIV-specific ADCC response.

Methods

The Sanger's method of sequencing was used to sequence the exon of FcγRIIIa receptor while the ADCC activity was determined using NK cell activation assay. The polymorphism in FcγRIIIa receptor was assessed in HIV-infected Indian individuals with or without HIV-specific ADCC antibodies and its influence on the magnitude of HIV-specific ADCC r

SUBMITTER: Talathi SP 

PROVIDER: S-EPMC6916223 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature