Most associations of early-life environmental exposures and genetic risk factors poorly differentiate between eczema phenotypes: the Generation R Study.

ABSTRACT:

Background

Childhood eczema is variable in onset and persistence.

Objectives

To identify eczema phenotypes during childhood, and their associations with early-life environmental and genetic factors.

Methods

In this study of 5297 children from a multiethnic population-based prospective cohort study, phenotypes based on parent-reported physician-diagnosed eczema from age 6 months to 10 years were identified using latent class growth analysis. Information on environmental factors was obtained using postal questionnaires. Four filaggrin mutations were genotyped and a risk score was calculated based on 30 genetic variants. Weighted adjusted multinomial models were used for association analyses.

Results

We identified the following five eczema phenotypes: never (76%),

SUBMITTER: Hu C 

PROVIDER: S-EPMC6916296 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature