Amiodarone use and the risk of acute pancreatitis: Influence of different exposure definitions.

ABSTRACT:

Purpose

The antiarrhythmic drug amiodarone has a long half-life of 60 days, which is often ignored in observational studies. This study aimed to investigate the impact of different exposure definitions on the association between amiodarone use and the risk of acute pancreatitis.

Method

Using data from the Dutch PHARMO Database Network, incident amiodarone users were compared to incident users of a different type of antiarrhythmic drug. Eighteen different definitions were applied to define amiodarone exposure, including dichotomized, continuous and categorized cumulative definitions with lagged effects to account for the half-life of amiodarone. For each exposure definition, a Cox proportional hazards model was used to estimate the hazard ratio (HR) of hospitalization for acu

SUBMITTER: Hempenius M 

PROVIDER: S-EPMC6916315 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature