Dataset Information

Treating nasal symptoms associated with rhinitis using the intranasal herbal ointment Biyeom-go: A prospective observational study.

ABSTRACT:

Objectives

The aim of the current study was to investigate the effectiveness and clinical feasibility of Biyeom-go for the treatment of nasal symptoms associated with rhinitis.

Design

Prospective observational study.

Setting

This study was conducted at the Woosuk Korean Medicine Medical Center in South Korea.

Participants

Fifty-eight patients with rhinitis participated in this study. All patients received Biyeom-go treatment >3 times daily for a total of 4 weeks.

Main outcome measures

The primary outcome was the total nasal symptom score. Mini-rhinoconjunctivitis quality of life questionnaire, nasal endoscopy index, total serum immunoglobulin E levels and immunologic factors in nasal lavage fluid were also measured.

Results

Biyeom-go administration was associated with significant improvements in total nasal symptoms scores (P < .0001) and mini-rhinoconjunctivitis quality of life questionnaire scores (P < .0001) in a time-dependent manner. The nasal endoscopy index also significantly improved at weeks 2 (P = .0049), 3 (P < .0001) and 4 (P = .0001) after Biyeom-go treatment. Significantly, increased interleukin-2 levels (P = .005) and decreased interleukin-8, chemokine (C-C motif) ligand (CCL) 5, chemokine (C-X-C motif) ligand (CXCL) 9, CCL2 and CXCL10 levels were observed in the nasal lavage fluid.

Conclusions

The present findings suggest that Biyeom-go may be beneficial for the management of rhinitis symptoms and rhinitis-associated quality of life. Further well-designed randomised controlled trials are needed to evaluate the effectiveness of Biyeom-go for rhinitis.

SUBMITTER: Son MJ

PROVIDER: S-EPMC6916331 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Publications

Treating nasal symptoms associated with rhinitis using the intranasal herbal ointment Biyeom-go: A prospective observational study.

Son Mi Ju MJ Jung Jeeyoun J Kim Young-Eun YE Yeum Chang-Sub CS Lee So Min SM Jung So Young SY Kwon Ojin O Kim Sungha S Kang Jeong-In JI Kim Hye-Lin HL Lee Jung-Eun JE Lee Dong-Hyo DH

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery 20191029 6

<h4>Objectives</h4>The aim of the current study was to investigate the effectiveness and clinical feasibility of Biyeom-go for the treatment of nasal symptoms associated with rhinitis.<h4>Design</h4>Prospective observational study.<h4>Setting</h4>This study was conducted at the Woosuk Korean Medicine Medical Center in South Korea.<h4>Participants</h4>Fifty-eight patients with rhinitis participated in this study. All patients received Biyeom-go treatment >3 times daily for a total of 4 weeks.<h4> ...[more]

PMID: 31468673

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Dataset Information

Treating nasal symptoms associated with rhinitis using the intranasal herbal ointment Biyeom-go: A prospective observational study.

Objectives

Design

Setting

Participants

Main outcome measures

Results

Conclusions

Publications

Treating nasal symptoms associated with rhinitis using the intranasal herbal ointment Biyeom-go: A prospective observational study.

Similar Datasets

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