Serum leptin, a potential predictor of long-term angiographic progression in Takayasu's arteritis.

ABSTRACT:

Aim

In patients with Takayasu's arteritis (TA), current biomarkers that properly reflect the progression of the vascular structure remain absent. We aimed to determine the serum leptin level to investigate its relationship with imaging changes and assess its value as a predictor for long-term radiological progression.

Method

This study included 34 untreated TA patients and 40 age-matched healthy controls. At baseline and during the 5-year follow-up, we assessed disease activity using Kerr's criteria and Indian Takayasu Clinical Activity Score (ITAS2010) and monitored laboratory biomarkers as well as imaging findings. Serum leptin levels were measured by enzyme-linked immunosorbent assay.

Results

The baseline serum leptin levels were significantly higher in TA patients

SUBMITTER: Ma L 

PROVIDER: S-EPMC6916353 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature