Gene expression profiling reveals a conserved microglia signature in larval zebrafish.

ABSTRACT: Microglia are the resident macrophages of the brain. Over the past decade, our understanding of the function of these cells has significantly improved. Microglia do not only play important roles in the healthy brain but are involved in almost every brain pathology. Gene expression profiling allowed to distinguish microglia from other macrophages and revealed that the full microglia signature can only be observed in vivo. Thus, animal models are irreplaceable to understand the function of these cells. One of the popular models to study microglia is the zebrafish larva. Due to their optical transparency and genetic accessibility, zebrafish larvae have been employed to understand a variety of microglia functions in the living brain. Here, we performed RNA sequencing of larval zebrafish microg

SUBMITTER: Mazzolini J 

PROVIDER: S-EPMC6916425 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature