A self-marker-like protein governs hemocyte allorecognition in Halocynthia roretzi.

ABSTRACT:

Background

Self-incompatibility, fusion/non-fusion reactions, and contact reactions (CRs) have all been identified as allorecognition phenomena in ascidians. CR is a reaction characteristic of the hemocytes of Halocynthia roretzi, whereby they release phenol oxidase (PO) upon contact with non-self hemocytes. Thus, these cells may represent a primitive form of the vertebrate immune system. In the present study, we focused on the CR of H. roretzi hemocytes and sought to identify self-marker proteins that distinguish between self and non-self cells.

Results

We initially generated a CR-inducing monoclonal antibody against the complete hemocyte membrane-protein complement (mAb11B16B10). This antibody was identified based on the differential induction of PO activity

SUBMITTER: Ema M 

PROVIDER: S-EPMC6916515 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature