Volume incompliance and transfusion are essential for transfusion-associated circulatory overload: a novel animal model.

ABSTRACT: BACKGROUND:Transfusion-associated circulatory overload (TACO) is the predominant complication of transfusion resulting in death. The pathophysiology is poorly understood, but inability to manage volume is associated with TACO, and observational data suggest it is different from simple cardiac overload due to fluids. We developed a two-hit TACO animal model to assess the role of volume incompliance ("first-hit") and studied whether volume overload ("second-hit") by red blood cell (RBC) transfusion is different compared to fluids (Ringer's lactate [RL]). MATERIALS AND METHODS:Male adult Lewis rats were stratified into a control group (no intervention) or a first hit: either myocardial infarction (MI) or acute kidney injury (AKI). Animals were randomized to a second hit of either RBC transfus

SUBMITTER: Klanderman RB 

PROVIDER: S-EPMC6916548 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature