Post-mortem multiple sclerosis lesion pathology is influenced by single nucleotide polymorphisms.

ABSTRACT: Over the last few decades, several common single nucleotide polymorphisms (SNPs) have been identified that correlate with clinical outcome in multiple sclerosis (MS), but the pathogenic mechanisms underlying the clinical effects of these SNPs are unknown. This is in part because of the difficulty in the functional translation of genotype into disease-relevant mechanisms. Building on our recent work showing the association of clinical disease course with post-mortem MS lesion characteristics, we hypothesized that SNPs that correlate with clinical disease course would also correlate with specific MS lesion characteristics in autopsy tissue. To test this hypothesis, 179 MS brain donors from the Netherlands Brain Bank MS autopsy cohort were genotyped for 102 SNPs, selected based on their repor

SUBMITTER: Fransen NL 

PROVIDER: S-EPMC6916567 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature