Overexpression of myeloid angiotensin-converting enzyme (ACE) reduces atherosclerosis.

ABSTRACT: Background: Macrophages are ubiquitous in all stages of atherosclerosis, exerting tremendous impact on lesion progression and plaque stability. Because macrophages in atherosclerotic plaques express angiotensin-converting enzyme (ACE), current dogma posits that local myeloid-mediated effects worsen the disease. In contrast, we previously reported that myeloid ACE overexpression augments macrophage resistance to various immune challenges, including tumors, bacterial infection and Alzheimer's plaque deposition. Here, we sought to assess the impact of myeloid ACE on atherosclerosis.

Methods: A mouse model in which ACE is overexpressed in myelomonocytic lineage cells, called ACE10, was generated and sequentially crossed with ApoE-deficient mice to create ACE^10/10

SUBMITTER: Okwan-Duodu D 

PROVIDER: S-EPMC6916669 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature