Modelling the intradermal delivery of microneedle array patches for long-acting antiretrovirals using PBPK.

ABSTRACT:

Introduction

Existing HIV therapy using oral antiretrovirals (ARVs) can result in pill fatigue and sub-optimal adherence. Microneedle array patches (MAPs) offer non-invasive, blood-free and painless drug delivery, and may improve patient adherence. The objective of this study was to develop a novel physiologically-based pharmacokinetic (PBPK) model to simulate the systemic pharmacokinetics of cabotegravir and rilpivirine MAPs using the intradermal route.

Methods

The developed PBPK models were qualified against observed pharmacokinetic data after intramuscular (IM) and intradermal administration of long-acting nanoformulated rilpivirine to rats, and for IM administration of both drugs to healthy adults. Qualified models were then utilised to estimate suitable MAP characterist

SUBMITTER: Rajoli RKR 

PROVIDER: S-EPMC6917207 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature