A transcriptome-based signature of pathological angiogenesis predicts breast cancer patient survival.

ABSTRACT: The specific genes and molecules that drive physiological angiogenesis differ from those involved in pathological angiogenesis, suggesting distinct mechanisms for these seemingly related processes. Unveiling genes and pathways preferentially associated with pathologic angiogenesis is key to understanding its mechanisms, thereby facilitating development of novel approaches to managing angiogenesis-dependent diseases. To better understand these different processes, we elucidated the transcriptome of the mouse retina in the well-accepted oxygen-induced retinopathy (OIR) model of pathological angiogenesis. We identified 153 genes changed between normal and OIR retinas, which represent a molecular signature relevant to other angiogenesis-dependent processes such as cancer. These genes robustly

SUBMITTER: Guarischi-Sousa R 

PROVIDER: S-EPMC6917213 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature