Toward more accurate prediction of caspase cleavage sites: a comprehensive review of current methods, tools and features.

ABSTRACT: As one of the few irreversible protein posttranslational modifications, proteolytic cleavage is involved in nearly all aspects of cellular activities, ranging from gene regulation to cell life-cycle regulation. Among the various protease-specific types of proteolytic cleavage, cleavages by casapses/granzyme B are considered as essential in the initiation and execution of programmed cell death and inflammation processes. Although a number of substrates for both types of proteolytic cleavage have been experimentally identified, the complete repertoire of caspases and granzyme B substrates remains to be fully characterized. To tackle this issue and complement experimental efforts for substrate identification, systematic bioinformatics studies of known cleavage sites provide important insights

SUBMITTER: Bao Y 

PROVIDER: S-EPMC6917222 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature