Exploring the functional impact of alternative splicing on human protein isoforms using available annotation sources.

ABSTRACT: In recent years, the emphasis of scientific inquiry has shifted from whole-genome analyses to an understanding of cellular responses specific to tissue, developmental stage or environmental conditions. One of the central mechanisms underlying the diversity and adaptability of the contextual responses is alternative splicing (AS). It enables a single gene to encode multiple isoforms with distinct biological functions. However, to date, the functions of the vast majority of differentially spliced protein isoforms are not known. Integration of genomic, proteomic, functional, phenotypic and contextual information is essential for supporting isoform-based modeling and analysis. Such integrative proteogenomics approaches promise to provide insights into the functions of the alternatively spliced

SUBMITTER: Sulakhe D 

PROVIDER: S-EPMC6917224 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature