External validation of clinical prediction rules for complications and mortality following Clostridioides difficile infection.

ABSTRACT:

Background

Several clinical prediction rules (CPRs) for complications and mortality of Clostridioides difficile infection (CDI) have been developed but only a few have gone through external validation, and none is widely recommended in clinical practice.

Methods

CPRs were identified through a systematic review. We included studies that predicted severe or complicated CDI (cCDI) and mortality, reported at least an internal validation step, and for which data were available with minimal modifications. Data from a multicenter prospective cohort of 1380 adults with confirmed CDI were used for external validation. In this cohort, cCDI occurred in 8% of the patients and 30-day all-cause mortality occurred in 12%. The performance of each tool was assessed using individual outcomes,

SUBMITTER: Beauregard-Paultre C 

PROVIDER: S-EPMC6917260 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature