Tyrphostin AG490 reduces inflammation and fibrosis in neonatal obstructive nephropathy.

ABSTRACT:

Background

Congenital obstructive nephropathy is the main cause of end-stage renal disease in infants and children. Renal insufficiency is due to impaired growth and maturation in the developing kidney with obstruction. Congenital obstructive nephropathy leads to cytokine mediated inflammation and the development of interstitial fibrosis. The Janus kinase-2 (JAK-2) and Signal Transducer and Activator of Transcription'-3 (STAT3) are involved in cytokine production, inflammation, and interstitial fibrosis.

Methods

We studied the role of JAK2/STAT3 in a model of congenital obstructive nephropathy using unilateral ureteral obstruction (UUO) in neonatal mice at the second day of life. Cytokine production, inflammation, and interstitial fibrosis were analyzed in obstructed and sha

SUBMITTER: Gasparitsch M 

PROVIDER: S-EPMC6917291 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature