Intestinal peroxisomal fatty acid β-oxidation regulates neural serotonin signaling through a feedback mechanism.

ABSTRACT: The ability to coordinate behavioral responses with metabolic status is fundamental to the maintenance of energy homeostasis. In numerous species including Caenorhabditis elegans and mammals, neural serotonin signaling regulates a range of food-related behaviors. However, the mechanisms that integrate metabolic information with serotonergic circuits are poorly characterized. Here, we identify metabolic, molecular, and cellular components of a circuit that links peripheral metabolic state to serotonin-regulated behaviors in C. elegans. We find that blocking the entry of fatty acyl coenzyme As (CoAs) into peroxisomal β-oxidation in the intestine blunts the effects of neural serotonin signaling on feeding and egg-laying behaviors. Comparative genomics and metabolomics revealed that interferin

SUBMITTER: Bouagnon AD 

PROVIDER: S-EPMC6917301 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature