α-Synuclein in blood cells differentiates Parkinson's disease from healthy controls.

ABSTRACT:

Objective

To determine whether blood cells expressed α-Syn can differentiate Parkinson's disease (PD) from healthy controls (HC).

Methods

The concentrations of α-Syn were determined in samples of blood cell pellets using a quantitative Lipid-ELISA assay. In addition, the levels of total protein, hemoglobin, iron and H-ferritin were determined. The study includes samples from the Biofind cohort (n = 46 PD and 45 HC) and results were validated with an additional cohort (n = 35 PD and 28 HC).

Results

A composite biomarker consisting of the concentrations of total α-Syn, proteinase-K resistant (PK^res ) α-Syn and phospho-Serine 129 α-Syn (PSer 129), is designed based on the analysis of the discovery BioFIND cohort. This composite biomarker differentiates a PD su

SUBMITTER: Abd Elhadi S 

PROVIDER: S-EPMC6917335 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature