Gene Expression Profiles in Primary Sjogren's Syndrome With and Without Systemic Manifestations.

ABSTRACT:

Objective

To investigate the gene expression profile in patients with Sjögren's syndrome that is characterized by different clinical phenotypes.

Methods

RNA from peripheral blood mononuclear cells was purified in 8 patients with glandular features (GFs) and widespread pain (WP) and 11 with extraglandular manifestations (EGMs) and then was analyzed by hybridization on a human gene chip exploring more than 40,000 human genes. Differentially expressed genes (DEGs) in the two subgroups (ie, those with false discovery rate-corrected P values ≤ 0.01) with respect to 20 healthy controls have been submitted to functional classification using a Gene Ontology database and were mapped to define the networks of protein to protein interactions (PPIs).

Results

The enriched p

SUBMITTER: Vitali C 

PROVIDER: S-EPMC6917337 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature