Integrated clinical, histopathological, and molecular data analysis of 190 central nervous system germ cell tumors from the iGCT Consortium.

ABSTRACT:

Background

We integrated clinical, histopathological, and molecular data of central nervous system germ cell tumors to provide insights into their management.

Methods

Data from the Intracranial Germ Cell Tumor Genome Analysis (iGCT) Consortium were reviewed. A total of 190 cases were classified as primary germ cell tumors (GCTs) based on central pathological reviews.

Results

All but one of the cases that were bifocal (neurohypophysis and pineal glands) and cases with multiple lesions including neurohypophysis or pineal gland were germinomas (34 of 35). Age was significantly higher in patients with germinoma than other histologies. Comparison between tumor marker and histopathological diagnoses showed that 18.2% of histopathologically diagnosed germinomas were marker p

SUBMITTER: Takami H 

PROVIDER: S-EPMC6917411 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature