Morphine Potentiates Dysbiotic Microbial and Metabolic Shifts in Acute SIV Infection.

ABSTRACT: Human Immunodeficiency Virus (HIV) pathogenesis has been closely linked with microbial translocation, which is believed to drive inflammation and HIV replication. Opioid drugs have been shown to worsen this symptom, leading to a faster progression of HIV infection to Acquired Immunodeficiency Syndrome (AIDS). The interaction of HIV and opioid drugs has not been studied at early stages of HIV, particularly in the gut microbiome where changes may precede translocation events. This study modeled early HIV infection by examining Simian Immunodeficiency Virus (SIV)-infected primates at 21 days or less both independently and in the context of opioid use. Fecal samples were analyzed both for 16S analysis of microbial populations as well as metabolite profiles via mass spectrometry. Our results in

SUBMITTER: Sindberg GM 

PROVIDER: S-EPMC6917429 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature