Multimodal Parcellations and Extensive Behavioral Profiling Tackling the Hippocampus Gradient.

ABSTRACT: The hippocampus displays a complex organization and function that is perturbed in many neuropathologies. Histological work revealed a complex arrangement of subfields along the medial-lateral and the ventral-dorsal dimension, which contrasts with the anterior-posterior functional differentiation. The variety of maps has raised the need for an integrative multimodal view. We applied connectivity-based parcellation to 1) intrinsic connectivity 2) task-based connectivity, and 3) structural covariance, as complementary windows into structural and functional differentiation of the hippocampus. Strikingly, while functional properties (i.e., intrinsic and task-based) revealed similar partitions dominated by an anterior-posterior organization, structural covariance exhibited a hybrid pattern refle

SUBMITTER: Plachti A 

PROVIDER: S-EPMC6917521 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature