Provitamin D₃ modulation through prebiotics supplementation: simulation based assessment.

ABSTRACT: Vitamin D is important in multiple health conditions. Vitamin D deficiency is prevalent globally even with exposure to adequate sunlight. Reduction in provitamin D₃ (7-dehydrocholesterol, 7-DHC) is an important cause of vitamin D₃ deficiency. Vitamin supplementation, food fortification, and use of probiotics are some approaches to reduce vitamin D₃ deficiency. This study investigates plausibility of 7-DHC biosynthesis through dietary prebiotics supplementation. Furthermore, it reports mechanistic details and constraints for the biosynthesis using flux balance analysis (FBA) simulations. The FBA simulations using co-metabolism models comprising human host and a resident bacterium (Faecalibacterium prausnitzii or Bacteroides thetaiotamicron) indicated increas

SUBMITTER: Gokhale S 

PROVIDER: S-EPMC6917722 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature