System OMICs analysis of Mycobacterium tuberculosis Beijing B0/W148 cluster.

ABSTRACT: Mycobacterium tuberculosis Beijing B0/W148 is one of the most widely distributed clusters in the Russian Federation and in some countries of the former Soviet Union. Recent studies have improved our understanding of the reasons for the "success" of the cluster but this area remains incompletely studied. Here, we focused on the system omics analysis of the RUS_B0 strain belonging to the Beijing B0/W148 cluster. Completed genome sequence of RUS_B0 (CP020093.1) and a collection of WGS for 394 cluster strains were used to describe the main genetic features of the population. In turn, proteome and transcriptome studies allowed to confirm the genomic data and to identify a number of finds that have not previously been described. Our results demonstrated that expression of the whiB6 which contain

SUBMITTER: Bespyatykh J 

PROVIDER: S-EPMC6917788 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature