Wireless, battery-free, fully implantable multimodal and multisite pacemakers for applications in small animal models.

ABSTRACT: Small animals support a wide range of pathological phenotypes and genotypes as versatile, affordable models for pathogenesis of cardiovascular diseases and for exploration of strategies in electrotherapy, gene therapy, and optogenetics. Pacing tools in such contexts are currently limited to tethered embodiments that constrain animal behaviors and experimental designs. Here, we introduce a highly miniaturized wireless energy-harvesting and digital communication electronics for thin, miniaturized pacing platforms weighing 110 mg with capabilities for subdermal implantation and tolerance to over 200,000 multiaxial cycles of strain without degradation in electrical or optical performance. Multimodal and multisite pacing in ex vivo and in vivo studies over many days demonstrate chronic stabilit

SUBMITTER: Gutruf P 

PROVIDER: S-EPMC6917818 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature