Real-Time Value Integration during Economic Choice Is Regulated by Orbitofrontal Cortex.

ABSTRACT: Neural correlates implicate the orbitofrontal cortex (OFC) in value-based or economic decision making [1-3]. Yet inactivation of OFC in rats performing a rodent version of the standard economic choice task is without effect [4, 5], a finding more in accord with ideas that the OFC is primarily necessary for behavior when new information must be taken into account [6-9]. Neural activity in the OFC spontaneously updates to reflect new information, particularly about outcomes [10-16], and the OFC is necessary for adjustments to learned behavior only under these conditions [4, 16-26]. Here, we merge these two independent lines of research by inactivating lateral OFC during an economic choice that requires new information about the value of the predicted outcomes to be incorporated into an alrea

SUBMITTER: Gardner MPH 

PROVIDER: S-EPMC6917829 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature