Epigenetic polypharmacology: A new frontier for epi-drug discovery.

ABSTRACT: Recently, despite the great success achieved by the so-called "magic bullets" in the treatment of different diseases through a marked and specific interaction with the target of interest, the pharmacological research is moving toward the development of "molecular network active compounds," embracing the related polypharmacology approach. This strategy was born to overcome the main limitations of the single target therapy leading to a superior therapeutic effect, a decrease of adverse reactions, and a reduction of potential mechanism(s) of drug resistance caused by robustness and redundancy of biological pathways. It has become clear that multifactorial diseases such as cancer, neurological, and inflammatory disorders, may require more complex therapeutic approaches hitting a certain biolog

SUBMITTER: Tomaselli D 

PROVIDER: S-EPMC6917854 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature