Generation of protective pneumococcal-specific nasal resident memory CD4⁺ T cells via parenteral immunization.

ABSTRACT: The generation of tissue-resident memory T cells (T_RM) is an essential aspect of immunity at mucosal surfaces, and it has been suggested that preferential generation of T_RM is one of the principal advantages of mucosally administered vaccines. We have previously shown that antigen-specific, IL-17-producing CD4⁺ T cells can provide capsular antibody-independent protection against nasal carriage of Streptococcus pneumoniae; but whether pneumococcus-responsive T_RM are localized within the nasal mucosa and are sufficient for protection from carriage has not been determined. Here, we show that intranasal administration of live or killed pneumococci to mice generates pneumococcus-responsive IL-17A-producing CD4⁺ mucosal T_RM. Furth

SUBMITTER: O'Hara JM 

PROVIDER: S-EPMC6917870 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature