Longitudinal Analysis of Pulmonary Function in Survivors of Congenital Diaphragmatic Hernia.

ABSTRACT:

Objective

To analyze longitudinal trends of pulmonary function testing in patients with congenital diaphragmatic hernia (CDH) followed in our multidisciplinary clinic.

Study design

This was a retrospective cohort study of CDH patients born between 1991 and 2013. A linear mixed effects model was fitted to estimate the trends of percent predicted forced expiratory volume in 1 second (FEV₁pp), percent predicted forced vital capacity (FVCpp), and FEV₁/FVC over time.

Results

Of 268 patients with CDH who survived to discharge, 119 had at least 1 pulmonary function test study. The FEV₁pp (P < .001), FVCpp (P = .017), and FEV₁/FVC (P = .001) decreased with age. Compared with defect size A/B, those with defect size C/D had lower FEV<

SUBMITTER: Dao DT 

PROVIDER: S-EPMC6917899 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature