Metabolomic markers of antepartum depression and suicidal ideation.

ABSTRACT:

Background

Recent analyses have described metabolomic markers for depression and suicidal ideation in non-pregnant adults. We examined the metabolomic profile of antepartum depression and suicidal ideation during mid-pregnancy, a time of high susceptibility to mood disorders.

Methods

We collected fasting blood from 100 pregnant Peruvian women and profiled 307 plasma metabolites using liquid chromatography-mass spectrometry. We used the Patient Health Questionnaire 9 to define antepartum depression (score  ≥ 10) and suicidal ideation (having thoughts that you would be better off dead, or of hurting yourself). Logistic regression was used to calculate odds ratios (ORs).

Results

Three triacylglycerol metabolites (C48:5 triacylglycerol [OR = =1.89; 95% confidence interval

SUBMITTER: Mitro SD 

PROVIDER: S-EPMC6917910 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature