Sleep restriction and testosterone concentrations in young healthy males: randomized controlled studies of acute and chronic short sleep.

ABSTRACT:

Objective

Low testosterone in men increases the risk for various disorders. Severe sleep restriction (SR) may reduce testosterone, but the effects of long-term short sleep are unknown. This study tested the effects of SR on circulating testosterone in healthy young men.

Design

Randomized controlled studies of SR vs habitual sleep (HS) in inpatient (study 1, n=14) and outpatient (study 2, n=13) settings.

Methods

Study 1 involved severe, acute SR (4 hours time in bed [TIB]) vs HS (9 hours TIB) for 5 nights; study 2 consisted of mild, long-term SR (HS 1.5 hours of sleep/night) vs HS for 6 weeks. Plasma testosterone levels were measured at baseline and end point (study 1) or baseline, week 3, and week 6 (study 2) of each phase. Linear model analyses to assess the effects

SUBMITTER: Smith I 

PROVIDER: S-EPMC6917985 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature