A plasma proteogenomic signature for fibromuscular dysplasia.

ABSTRACT:

Aims

Fibromuscular dysplasia (FMD) is a poorly understood disease that predominantly affects women during middle-life, with features that include stenosis, aneurysm, and dissection of medium-large arteries. Recently, plasma proteomics has emerged as an important means to understand cardiovascular diseases. Our objectives were: (i) to characterize plasma proteins and determine if any exhibit differential abundance in FMD subjects vs. matched healthy controls and (ii) to leverage these protein data to conduct systems analyses to provide biologic insights on FMD, and explore if this could be developed into a blood-based FMD test.

Methods and results

Females with 'multifocal' FMD and matched healthy controls underwent clinical phenotyping, dermal biopsy, and blood draw. Using du

SUBMITTER: Olin JW 

PROVIDER: S-EPMC6918065 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature