Genome-wide association study identifies locus at chromosome 2q32.1 associated with syncope and collapse.

ABSTRACT:

Aims

Syncope is a common condition associated with frequent hospitalization or visits to the emergency department. Family aggregation and twin studies have shown that syncope has a heritable component. We investigated whether common genetic variants predispose to syncope and collapse.

Methods and results

We used genome-wide association data on syncope on 408 961 individuals with European ancestry from the UK Biobank study. In a replication study, we used the Integrative Psychiatric Research Consortium (iPSYCH) cohort (n = 86 189), to investigate the risk of incident syncope stratified by genotype carrier status. We report on a genome-wide significant locus located on chromosome 2q32.1 [odds ratio = 1.13, 95% confidence interval (CI) 1.10-1.17, P = 5.8 × 10-15], with lead sin

SUBMITTER: Hadji-Turdeghal K 

PROVIDER: S-EPMC6918066 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature