Mining the Methylome Reveals Extensive Diversity in Staphylococcus epidermidis Restriction Modification.

ABSTRACT: Staphylococcus epidermidis is a significant opportunistic pathogen of humans. Molecular studies in this species have been hampered by the presence of restriction-modification (RM) systems that limit introduction of foreign DNA. Here, we establish the complete genomes and methylomes for seven clinically significant, genetically diverse S. epidermidis isolates and perform the first systematic genomic analyses of the type I RM systems within both S. epidermidis and Staphylococcus aureus Our analyses revealed marked differences in the gene arrangement, chromosomal location, and movement of type I RM systems between the two species. Unlike S. aureus, S. epidermidis type I RM systems demonstrate extensive diversity even within a single genetic lineage. This is contrary to current assumptions and

SUBMITTER: Lee JYH 

PROVIDER: S-EPMC6918075 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature