Controlled Cellular Delivery of Amphiphilic Cargo by Redox-Responsive Nanocontainers.

ABSTRACT: The specific transport of amphiphilic compounds such as fluorescently labeled phospholipids into cells is a prerequisite for the analysis of highly dynamic cellular processes involving these molecules, e.g., the intracellular distribution and metabolism of phospholipids. However, cellular delivery remains a challenge as it should not affect the physiological integrity and morphology of the cell membrane. To address this, polymer nanocontainers based on redox-responsive cyclodextrin (CD) amphiphiles are prepared, and their potential to deliver fluorescently labeled phospholipids to intracellular membrane compartments is analyzed. It is shown that mixtures of reductively degradable cyclodextrin amphiphiles and different phospholipids form liposome-like vesicles (CD-lipid vesicles, C_SS</

SUBMITTER: de Vries WC 

PROVIDER: S-EPMC6918114 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature