Self-Supply of O₂ and H₂O₂ by a Nanocatalytic Medicine to Enhance Combined Chemo/Chemodynamic Therapy.

ABSTRACT: Combined chemo/chemodynamic therapy is a promising strategy to achieve an improved anticancer effect. However, the hypoxic microenvironment and limited amount of H₂O₂ in most solid tumors severely restrict the efficacy of this treatment. Herein, the construction of a nanocatalytic medicine, CaO₂@DOX@ZIF-67, via a bottom-up approach is described. CaO₂@DOX@ZIF-67 simultaneously supplies O₂ and H₂O₂ to achieve improved chemo/chemodynamic therapy. In the weakly acidic environment within tumors, CaO₂@DOX@ZIF-67 is broken down to rapidly release the Fenton-like catalyst Co²⁺ and the chemotherapy drug doxorubicin (DOX). The unprotected CaO₂ reacts with H₂O to generate both O

SUBMITTER: Gao S 

PROVIDER: S-EPMC6918120 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature