Inter-Laboratory Comparison of Metabolite Measurements for Metabolomics Data Integration.

ABSTRACT: One of the current problems in the field of metabolomics is the difficulty in integrating data collected using different equipment at different facilities, because many metabolomic methods have been developed independently and are unique to each laboratory. In this study, we examined whether different analytical methods among 12 different laboratories provided comparable relative quantification data for certain metabolites. Identical samples extracted from two cell lines (HT-29 and AsPc-1) were distributed to each facility, and hydrophilic and hydrophobic metabolite analyses were performed using the daily routine protocols of each laboratory. The results indicate that there was no difference in the relative quantitative data (HT-29/AsPc-1) for about half of the measured metabolites among t

SUBMITTER: Izumi Y 

PROVIDER: S-EPMC6918145 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature