Mechanically Reinforced Gelatin Hydrogels by Introducing Slidable Supramolecular Cross-Linkers.

ABSTRACT: Tough mechanical properties are generally required for tissue substitutes used in regeneration of damaged tissue, as these substitutes must be able to withstand the external physical force caused by stretching. Gelatin, a biopolymer derived from collagen, is a biocompatible and cell adhesive material, and is thus widely utilized as a component of biomaterials. However, the application of gelatin hydrogels as a tissue substitute is limited owing to their insufficient mechanical properties. Chemical cross-linking is a promising method to improve the mechanical properties of hydrogels. We examined the potential of the chemical cross-linking of gelatin hydrogels with carboxy-group-modified polyrotaxanes (PRXs), a supramolecular polymer comprising a poly(ethylene glycol) chain threaded into the

SUBMITTER: Lee DH 

PROVIDER: S-EPMC6918157 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature