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Production of a New Cyclic Depsipeptide by the Culture Broth of Staphylococcus sp. Isolated from Corallinaofficinalis L.

ABSTRACT: A new cyclic depsipeptide (1) has been isolated from culture broth of Staphylococcus sp. (No. P-100826-4-6) derived from Corallina officinalis L., together with the known compounds indol-3-carboxylic acid (2), 1,5-dideoxy-3-C-methyl arabinitol (3), thymine (4), uracil (5), cyclo (L-pro-L-omet) (6) and macrolactin B (7). The structure of (1) was established to be cyclo (2α, 3-diaminopropoinc acid-L-Asn-3-β-hydroxy-5-methyl-tetradecanoic acid-L-Leu1-L-Asp-L-Val-L-Leu2-L-Leu3) by extensive spectroscopic techniques including 1H NMR, 13C NMR, 1H‒1H COSY, HMBC, HSQC, NOESY, and HRFABMS. The antimicrobial activities of compounds 1-7 were evaluated. Compounds 1-5, and 7 showed moderate antimicrobial activity while compound 6 exhibited a potent antimicrobial and antifungal activities.

SUBMITTER: Abdelhameed RFA

PROVIDER: S-EPMC6918221 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Production of a New Cyclic Depsipeptide by the Culture Broth of Staphylococcus sp. Isolated from Corallina officinalis L.

Abdelhameed Reda F A RFA Elhady Sameh S SS Noor Ahmad O AO Almasri Diena M DM Bagalagel Alaa A AA Maatooq Galal T GT Khedr Amgad I M AIM Yamada Koji K

Metabolites 20191111 11

A new cyclic depsipeptide (1) has been isolated from culture broth of Staphylococcus sp. (No. P-100826-4-6) derived from Corallina officinalis L., together with the known compounds indol-3-carboxylic acid (2), 1,5-dideoxy-3-C-methyl arabinitol (3), thymine (4), uracil (5), cyclo (L-pro-L-omet) (6) and macrolactin B (7). The structure of (1) was established to be cyclo (2α, 3-diaminopropoinc acid-L-Asn-3-β-hydroxy-5-methyl-tetr ...[more]

PMID: 31718059

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