Metabolomics Test Materials for Quality Control: A Study of a Urine Materials Suite.

ABSTRACT: There is a lack of experimental reference materials and standards for metabolomics measurements, such as urine, plasma, and other human fluid samples. Reasons include difficulties with supply, distribution, and dissemination of information about the materials. Additionally, there is a long lead time because reference materials need their compositions to be fully characterized with uncertainty, a labor-intensive process for material containing thousands of relevant compounds. Furthermore, data analysis can be hampered by different methods using different software by different vendors. In this work, we propose an alternative implementation of reference materials. Instead of characterizing biological materials based on their composition, we propose using untargeted metabolomic data such as nu

SUBMITTER: Bearden DW 

PROVIDER: S-EPMC6918257 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature