Molecular thermodynamics of receptor competition for endocytic uptake.

ABSTRACT: Endocytic uptake of receptors from the cell surface plays an important role in diverse processes from cell signaling to nutrient internalization. Understanding the mechanisms by which endocytic structures select receptors for internalization is of fundamental importance to our understanding of cellular physiology. Binding of receptors to the endocytic protein machinery is known to facilitate receptor loading into endocytic structures. However, many receptor species use the same small set of biochemical motifs to interact with the endocytic machinery, suggesting that receptors may compete for a limited number of binding sites within endocytic structures. Previous studies have shown that such competition can substantially modify receptor uptake. However, a predictive biophysical understandin

SUBMITTER: DeGroot ACM 

PROVIDER: S-EPMC6918483 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature