Evaluation of gene-environment interactions for colorectal cancer susceptibility loci using case-only and case-control designs.

ABSTRACT:

Background

Genome-wide association studies (GWAS) have identified more than 40 colorectal cancer susceptibility loci, but only a small fraction of heritability was explained. To account for missing heritability, we investigated gene-environment interactions (G × Es) between GWAS-identified single-nucleotide polymorphisms (SNPs) and established risk or protective factors for colorectal cancer using both case-only and case-control study designs.

Methods

Data on 703 colorectal cancer cases and 1406 healthy controls from the National Cancer Center in Korea were used. We tested interactions between 31 GWAS-identified SNPs and 13 established risk or protective factors for colorectal cancer (family history, body mass index, history of colorectal polyps, inflammatory bowel disease,

SUBMITTER: Song N 

PROVIDER: S-EPMC6918639 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature